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Paclitaxel
Paclitaxel
Product name: Paclitaxel
CAS#33069-62-4 Purity:98% 99.5%
Molecular Formula:C47H51NO14
Molecular Weight:853.92g/mol
Tricyclic Diterpenes chemical compound
Physical properties: white crystalline powder. No smell, no taste. Difficult to dissolve in water, soluble in chloroform, acetone and other organic solvents.
Paclitaxel extraction, purification process flow: Bark of the crushed (the finer the better), 85% to 95% alcohol (feed liquid ratio is how much?) 55 - 35 degrees Celsius hot reflux extraction three times (each time need to how much time?) 50 - 70 DEG C, vacuum concentration and heat measuring the proportion of 1.1 ~ 1.2g/ml, chloroform extraction, extraction liquid was condensed into a paste, taxol content of 1% chloroform cream, the taxol content of 1% chloroform ointment with chloroform dissolved completely, and silica gel dry mixing, sieving, filling into the column, chloroform methanol gradient elution, TLC detection, segment merging concentration, the taxol content was 5 ~ 8% semi-finished products, paclitaxel content 5 ~ 8% semi-finished products with acetone dissolved completely, and silica gel dry mixing, sieving, filling into the column, acetone and petroleum ether elution, TLC detection, segmentation with concentration, the taxol content was 20 ~ 25% semi-finished products with acetone and petroleum ether system 3 ~ 4 times of crystallization, filtration, vacuum drying to 50 DEG C, the taxol content 75 ~ 80% semi-finished products, 16Mpa pressure chromatography, TLC detection and segmentation And concentrated, the target segment concentrates acetone petroleum ether crystallization, filtration, drying, to obtain paclitaxel content more than 99.5% products.
Properties: Product is white or white crystalline powder.
Haoxiang Bio Production specifications: 20mg, 50mg, 100mg, 1g, 10g, 100g, 1kg, 50kg
Packing: Aluminum foil, plastic